VEGFA and rheumatoid arthritis: The excessive expression of VEGF in RA-inflamed synovial tissue has been broadly reported on [49] and the double labeling of endothelium and pericytes/smooth muscle mural cells of synovial arthroscopic biopsies from RA, revealed that immature vessels were present from the earliest phases of RA, and their density increased in patients with a longer disease duration [50].