Further in-depth characterization has shown that two human disease variants in TRPM3 (V990/2M and P1090/2Q), which result in developmental and epileptic encephalopathy (DEE), can cause increased responses to PS, leading to elevated cytosolic calcium levels compared to wild-type TRPM3 [27,28]. This evidence concerns the gene TRPM3 and developmental and epileptic encephalopathy.