Recently, multi-omics analyses of HBc transfected cells revealed that HBc protein promotes the expression of multiple metabolic enzymes and the secretion of metabolites from hepatoma cells modifying the metabolic characteristics of HCC cells, and contributes to HBV-related metabolic dysregulation through the modulation of glycolysis and amino acid metabolism. The gene discussed is KRT88P; the disease is hepatocellular carcinoma.