APP and Alzheimer disease: Hong et al. (2016) found that human APP (hAPP) (J20) transgenic mice, a mouse model which overexpresses hAPP with mutations linked to familial AD (Swedish and Indiana mutations) yielding vast amount of Aβ plaques at young age, showed an increase in C1q from approximately 1 month of age compared with its WT mice, and this was prior to the formation of Aβ plaques.