Treatment with celecoxib possesses the ability to promote apoptosis, inhibit cell proliferation, and induce cell cycle arrest in HCC cells through the upregulation of E-cadherin protein via the inhibition of the Cyclooxygenase-2 (COX-2) prostaglandin E2 (PGE2)-p-Akt/p-ERK cascade (Table 1) [55]. The gene discussed is PTGS2; the disease is hepatocellular carcinoma.