AIRE and autoimmune hepatitis: Some of these factors are incompletely confirmed, such as CTLA4, FAS/FASL, AIRE, and GATA2 mutations, but the predisposing HLA-D allele, SH2B3 risk allele, female gender, age, hormonal status, and exposure to viral and drug triggers have been demonstrated to be associated with the risk of developing autoimmune hepatitis.