Some of these factors are incompletely confirmed, such as CTLA4, FAS/FASL, AIRE, and GATA2 mutations, but the predisposing HLA-D allele, SH2B3 risk allele, female gender, age, hormonal status, and exposure to viral and drug triggers have been demonstrated to be associated with the risk of developing autoimmune hepatitis. Here, SH2B3 is linked to autoimmune hepatitis.