SH2B3 and autoimmune disease: This report revealed an association between AIH and two susceptibility genotypes: HLA-DRB1*0301 and DRB1*0401 and also variants of SH2B3 (also known as SH2B adaptor protein 3 or as Lnk), which are associated with autoimmune diseases, such as AIH, type 1 diabetes mellitus, celiac disease, and rheumatoid arthritis [50].