In MDA-MB-231 tumor model, sulforaphane suppressed the malignant proliferation and mammosphere formation of BCSCs in TNBC via Cripto-mediated pathway and decreased the expression of stem-related embryonic oncogenes CRIPTO-1/TDGF1, CRIPTO-3/TDGF1P3 and various stem cell markers including aldehyde dehydrogenase 1A1 (ALDH1A1), Wingless-related integration site (WNT3), and Notch receptor 4 (NOTCH 4) [101]. This evidence concerns the gene NOTCH4 and neoplasm.