HMGB1 and neoplasm: Triptolide significantly suppressed MDA-MB-231 cell viability and clonogenic ability via inhibiting High Mobility Group Box 1 (HMGB1) mRNA expression and its associated factors, e.g., Toll-like receptor 4 (TLR4) and phosphorylated form (p) of NF-κB p65 and inhibited MDA-MB-231 tumor growth [76].