The sequential release of EGCG followed by paclitaxel from the core/shell PLGA-casein nanoparticle sensitized paclitaxel resistant MDA-MB-231 cells to paclitaxel, induced their apoptosis, inhibited NF-κB activation, and downregulated the key genes associated with angiogenesis, tumor metastasis, and survival [154]. This evidence concerns the gene NFKB1 and neoplasm.