Prophylactic treatment of healthy mice with P2Et increased the numbers of CD4+ and CD8+ activated T cells, NK cells, and DCs; however, Treg cells, MDSC, and IL-6 were also increased, which may result in failure to establish a protective effect against the control of tumor growth and metastasis in transplantable models of breast cancer [192]. This evidence concerns the gene CD8A and breast carcinoma.