Furthermore, DET induced endoplasmic reticulum (ER) stress-mediated apoptosis by regulating protein disulfide isomerase, 78 kDa glucose-regulated protein (GRP78), thioredoxin domain-containing protein 5, caspase-12, caspase-3, and PARP proteins, and suppressed proteasomal proteolysis in breast cancer cells [61]. The gene discussed is HSPA5; the disease is breast carcinoma.