As shown in Figure 7D, the inhibition of KCa1.1 in LNCaP spheroids did not affect the expression level of AR; however, IL-1β and/or IL-8-producing, tumor-infiltrating non-cancerous cells, such as tumor-associated macrophages cells in the TME, may be responsible for the AR transcriptional repression-mediated antiandrogen resistance in PCSCs. This evidence concerns the gene KCNMA1 and neoplasm.