MAPK6 and obesity due to melanocortin 4 receptor deficiency: In a previous pilot GWAS study conducted on pediatric obesity patients, DNA screening was applied to identify the SNPs (Single nucleotide polymorphism, rs9916229, rs756942) on mitogen-activated protein kinase, kinase 6 (MAP2K6, MEK6), which are correlated with RMR and obesity prevalence [14].