MFN2 and heart failure: Our findings reveal that metalloproteinase activation, EE leakage, E-M uncoupling, altered Mfn2/Drp1 ratios, and MM uncoupling during AVF heart failure were the abundant features but treatment with HCQ could successfully mitigate deleterious CHF phenotype highlighting the potential application of CHQ as a possible therapeutic option for the clinical consideration [76,77,78,79].