SOD1 and cancer: Taking into account the causative role of free radicals (or reactive oxygen species) in inducing oxidative stress during cancer [36,37], we evaluated the antioxidant activity of RBEs and their purified monomers using assays that evaluated the following: intracellular ROS generation, intracellular GSH/glutathione disulfide (GSSG) ratio, and intracellular SOD activity.