In agreement with the fact that this event causes the loss of the E5 gene [68,69,77], the latter is expressed in cervical L-SILs [70] but not in cervical carcinomas [68]: this underlies the established belief that E5 plays a role mostly in the early stages of cervical carcinogenesis [63,66,67,68,69,77]. The gene discussed is ARHGEF15; the disease is cervical carcinoma.