The CSCs, whose number in the SCC lesions directly parallels the tumor grade [91,92,94,95,222] are believed to arise from the dedifferentiation of mutated somatic cells and/or the transformation of stem cells [107]: both of these events are largely attributable to the loss of p53 which is undoubtedly one of the key steps in HR-HPV-promoted cervical carcinogenesis. This evidence concerns the gene TP53 and neoplasm.