The rearrangement of the cytoskeleton is followed by the recruitment of MMPs and CD44, both expressed by the uterine cervical SCC cells [88,230], to the forming protrusions: there, CD44 and the MMPs may aggregate, giving rise to macromolecular complexes which on one side mediate cancer cell adhesion to the extracellular matrix, and on the other induce matrix degradation [261]. This evidence concerns the gene CD44 and cancer.