Among them, HIF-1 is very effective as it promptly stimulates the Oct4 and Sox2 transcription factors at inducing the stem cell phenotype (Figure 3) [107]; at the same time, HIF-1 favors stem cell survival by promoting lactate production via glycolysis (Figure 3), a metabolic program which is exacerbated in both stem and cancer cells, rendering them less dependent on oxygen supply than non-transformed, well-differentiated cells [54,211]. This evidence concerns the gene HIF1A and cancer.