In hypoxia, HIF-1α is stabilized and interacts with transcriptional coactivators to promote the expression of target genes such as that coding for vascular endothelial growth factor (VEGF)-A: the latter, in turn, stimulates angiogenesis, that is the formation of new blood vessels directed at nourishing the growing tumor (Figure 3) [182,190,192,193]. Here, HIF1A is linked to neoplasm.