Additionally, in a subpopulation of pre-leukemic hematopoietic stem/progenitor cells from primary human AML that carry DNA (cytosine-5)-methyltransferase 3 alpha (DNMT3A) mutations, high levels of pseudo-mutant p53 are dominantly detected over the wild-type conformation, while p53 in leukemic blasts shows mainly the wtp53 conformation [217]. Here, DNMT3A is linked to acute myeloid leukemia.