DNAJB1 and neoplasm: Moreover, DNAJB1/HDJ1 binds to mitogen-inducible gene-6 (MIG6), a tumor suppressor that inhibits the EGFR signaling, which decreases the protein level of MIG6 by enhancing its ubiquitination, leading to upregulation of the EGFR signaling pathway in A549 lung adenocarcinoma and HCT116 CRC cell lines [132,134].