Specifically, DNAJB1/HDJ1 binds to and stabilizes MDM2, a major ubiquitin ligase of p53; however, this interaction inhibits MDM2’s activity on p53, leading to p53 activation, while DNAJB1/HDJ1 knockdown increases cell proliferation and tumor growth of MCF7 cells in a manner dependent on wtp53 [41]. The gene discussed is DNAJB1; the disease is neoplasm.