IQGAP1 and colorectal carcinoma: High levels of DNAJB6/MRJ are associated with poor outcomes in patients with CRC, while knockdown of DNAJB6/MRJ in HCT116 and SW480 CRC cells inhibits invasion and pulmonary metastases with reduced IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) levels, a scaffold protein of the MAP kinase pathway [123].