AKT1 and esophageal squamous cell carcinoma: Moreover, in esophageal squamous cell carcinoma (ESCC), nuclear localization of DNAJB6/MRJ is associated with favorable outcomes in patients with ESCC, while DNAJB6a, an isoform that contains a nuclear localization signal, reduces proliferation and xenograft tumor growth with reduced AKT signaling [122].