A fusion gene of DNAJB1/HDJ1 and PRKACA (protein kinase cAMP-activated catalytic subunit alpha), resulting from an ~400 kb of in-frame deletion on chromosome 19, is found in nearly all cases of fibrolamellar hepatocellular carcinoma (FL-HCC) [115]. The gene discussed is DNAJB1; the disease is hepatocellular carcinoma.