Most adipokines, including leptin, tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), resistin, or retinol-binding protein 4 (RBP4), are augmented in the obese state and promote inflammatory reactions, leading to obesity-associated comorbidities [6]. This evidence concerns the gene RBP4 and obesity due to melanocortin 4 receptor deficiency.