PTEN and posterior cortical atrophy: Multiple genomic studies based on whole-exome sequencing or transcriptome data allowed for the identification of several molecular pathways altered in advanced PCa: not only the most frequent and explored androgen receptor signaling pathway, present in over 60% of metastatic CRPC (mCRPC) cases, but also ETS, TP53, DNA damage repair (DDR) genes, phosphatase and tensin homolog (PTEN)-phosphatidylinositol 3-kinase (PI3K)-AKT signaling, and mismatch repair genes [12,13].