β-apopicropodophyllin (APP) is a derivative of PPT that disturbs microtubule polymerization and induces apoptosis of NSCLC cells such as NCI-H460, NCI-H1299, A549, and their xenografts in nude mice in in vivo models, suggesting that it may be a candidate anti-cancer agent, as reported in our previous studies [22,23]. Here, PPIB is linked to cancer.