To compensate the antigiogenic effect, thus protecting the host, the infection with A. fumigatus triggers proangiogenic effects, including the production of proinflammatory factors such as tumor necrosis factor alpha (TNFα), hypoxia-inducible factor 1-alpha (HIF1α), and interleukin (IL-8), thus recruiting the polymorphonuclear leucocytes (PMNLs) and leading to the burst of ROS, including H2O2. Here, HIF1A is linked to infection.