Gliotoxin can also induce the apoptosis of chronic lymphocytic leukemia cells (CLLs) (IC50 between 0.1 and 1 μM), associated with the inhibition of the NOTCH2/FCER2 (CD23) axis, together with the upregulation of the NOTCH3/NR4A1 axis and NF-κB factor [87,88], thus providing a novel strategy for the treatment of CLLs. Here, FCER2 is linked to B-cell chronic lymphocytic leukemia.