Car shows an antiangiogenic activity associated with its antitumor effect against different cancers [132]; conversely, a preventive treatment with Car of hypoxia-induced neurotoxicity in rats (250 mg/kg) increases hypoxia inducible factor-1α (HIF-1α), VEGF, and its receptor VEGFR1 stimulating angiogenesis [133]. This evidence concerns the gene FLT1 and cancer.