Our study with uL5 knocked down HEK293T cells, on the contrary, gives information not so much on the gene expression landscape typical of chronic uL5 deficiency, but on the landscape changes that appear when a deficiency of uL5 occurs, i.e., general changes in gene expression that can be caused by somatic mutations in the RPL11 gene and initiate cancer. This evidence concerns the gene RPL11 and hyperinsulinemic hypoglycemia, familial, 4.