As mentioned in the Introduction, early studies on U2OS (human osteosarcoma) cells have shown that an increase in the content of uL5 leads to a decrease in the level and activity of the c-Myc proto-oncogene, presumably due to a decrease in the stability of its mRNA caused by the binding of a specific miRNA to the 3′ UTR of c-Myc mRNA [8,9]. The gene discussed is MYC; the disease is osteosarcoma.