This model has been used to determine the role of P-glycoprotein(P-gp) in transport of drugs used for diabetic patients like repaglinide (REG) in intestine [114], as well as to study P-gp-mediated efflux of anti-cancer agents using [3H]vinblastine, [14C]doxorubicin, and verapamil compounds [115]. This evidence concerns the gene PGP and cancer.