When considering both Normal (n = 16) and AMD (n = 14) whole blood samples, Horvath’s multi-tissue clock displayed a small increase in EAA (Normal: +5.07 years; AMD: +3.53 years) (Figure 2D); whereas the Hannum (Normal: −12.21 years; AMD: −13.69 years) (Figure 2E) and Skin & Blood (Normal: −4.27 years; AMD: −6.78 years) clocks displayed decreases in EAA across groups (Figure 2F). The gene discussed is CLOCK; the disease is age-related macular degeneration.