As shown in Figure 2, LYVE-1 fluorescence was widespread throughout the tumor sections in the control samples and occupied 25.2 ± 1.5% of the investigated area (0.96 mm2), whereas treatment with MSNs reduced the fluorescence area by 14.2 ± 0.8%, where the LYVE-1-positive cells were visualized in discrete portions of the sample. This evidence concerns the gene LYVE1 and neoplasm.