In this study it was shown that in rats subjected to endotoxemia, hypotension was reduced and the production of Tumor Necrosis Factor α (TNFα) in the heart, liver, spleen, and other organs, was blocked by intracerebroventricular injections of CNI-1493 (a p38 MAPK (mitogen-activated protein kinase) inhibitor, derived from guanylhydrazone, which blocks cytokine secretion). This evidence concerns the gene TNF and serum lipopolysaccharide activity.