KDM6B and Leigh syndrome: Based on the results that Jmjd3 is expressed not only in blood vessels but also in macrophages in the cauda equina of LSS rats (see Figure 2D), as well as the previous reports showing that Jmjd3 modulates the proinflammatory macrophage response [23,24], we speculated that Jmjd3 might also be involved in the activation of macrophage infiltration in the cauda equina of LSS rats.