Also, CLDN6 regulates the PI3K/AKT/mTOR signaling pathway in HEC-1B endometrial carcinoma cells [68] and EGFR/AKT/mTOR signaling pathway in HepG2 cells [65], but the mechanisms of how CLDN6 affects the signaling pathway in both HEC-1B and HepG2 cells remain to be verified. The gene discussed is CLDN6; the disease is endometrial carcinoma.