In the present study, we revealed that microtubule plus end anchor protein APC has an important role in the podocyte vesicle transport in the PAN-induced minimal change nephrotic syndrome, and APC1638T gene mutation reduced podocyte α-tubulin expression and reduced basal endocytosis vesicles, resulting in reduction of albuminuria in the PAN-induced nephrotic syndrome. The gene discussed is APC; the disease is nephrotic syndrome.