IFNA1 and glioblastoma: Single-cell RNA-seq analysis of GBM-infiltrating MDMs revealed a variety of macrophage clusters including: (1) a monocyte–macrophage transition; (2) phagocytic active/high lipid metabolism; (3) hypoxic/glycolysis active; (4) SEPP1low/ microglia-like; (5) SEPP1high/anti-inflammatory cluster and a (6) IFN-induced signature cluster [18].