EGFR and central nervous system cancer: Additionally, the combined activity between epidermal growth factor receptor (EGFR) and the EGFRvIII in glioma cells induces signaling through KRAS to increase the expression of CCL2 [42], a ligand that binds with high affinity to the CCR2 receptor expressed by monocytes derived from the peripheral blood and the skull bone marrow [4,43].