It has been widely shown that chronic stress-induced behavioral changes are associated with neuronal atrophy and reduced levels of BDNF and phosphorylated/activated TrkB in the prefrontal cortex and the hippocampus in rodents, while almost all antidepressants can restore BDNF level and activate TrkB receptors in rodent chronic stress models (reviewed in [7]). Here, BDNF is linked to Atrophy.