Previously, our team reported that while conducting clinical studies on inducible nitric oxide synthase (iNOS) as a potential new blood biomarker for the onset of sepsis, it was discovered that the iNOS in blood was exclusively contained in circulating microvesicle nanoparticles and was only present in the blood of individuals who were already septic or who would become septic in the next 24 to 48 h [6,7]. The gene discussed is NOS2; the disease is Sepsis.