In contrast, Bryant and colleagues reported that EGF-dependent E-cadherin co-internalization occurs in a breast carcinoma cell line, along with cadherin-binding proteins p120 and β-catenin; EGF stimulation resulted in Rac1-modulated micropinocytosis, rather than caveolin-mediated endocytosis [17] (Figure 2). The gene discussed is CDH1; the disease is breast carcinoma.