NFKB1 and asthma: On the other hand, the replacement of guanine with adenine at position −201 is associated with a change in the affinity of the nuclear transcription factor kB (NF-kB, kappa B) for enhancer A. It has also been shown that the presence of the GG genotype at position −964 correlates with a higher incidence of asthma among the children of mothers with this disease, while the AA genotype is associated with a higher incidence of asthma among children of healthy mothers [17,18].