To confirm that the suppressive effects of 1,25(OH)2D3 and 20S(OH)D3 were mediated by LAIR-1, both LAIR-1+/+ and LAIR-1−/− mice were immunized with CII/CFA to induce arthritis followed by treatment orally with either vehicle control or 1,25(OH)2D3. The gene discussed is LAIR1; the disease is Arthritis.