Consistent with the involvement of an SCF E3 ubiquitin ligase complex in the regulation of Sufu, a recent study by Wang et al. showed that ROC1/RBX1, the RING component of cullin-based E3 ubiquitin ligase implicated in in bladder cancer cell survival and progression, could target Sufu for ubiquitination and degradation, leading to dissociation of Gli2 from Sufu and activation of Hh pathway in bladder cancer cells [69]. This evidence concerns the gene CACUL1 and urinary bladder cancer.