One study showed that high mobility group box protein SOX9 is a transcriptional target of Gli1 in KRAS-driven pancreatic ductal adenocarcinoma (PDA) and acts in a positive feedback loop to stabilize Gli1 by binding and sequestrating β-TRCP away from Gli1, which is thought to promote PDA [122]. The gene discussed is KRAS; the disease is Patent ductus arteriosus.