To determine if ADPKD is associated with any changes to the expression of these intragenic loci, gene expression analysis of three miRNA found within the PKD1 gene and its promoter (miR-1225, miR-3180-5p, and miR-4516) was performed in five human ADPKD kidney samples and three non-ADPKD samples [51]. This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.