In contrast, a wide variation in miR-4516 expression was observed in ADPKD tissues when compared to non-ADPKD kidney tissue, suggesting some dysregulation in the expression of this miRNA (which is located within intron one of PKD1, 2.6 kb from the transcription start site; see Figure 1). The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.