In the U.S. National Cancer Institute (NCI) Genomic DNA Commons (https://gdc.cancer.gov/ [accessed on 1 June 2021]), where mutation incidences of various cancer-related genes are constantly updated, the present somatic mutations in the cohort analysis of the TP53 gene detected in various human adult cancer tissues was 68.4% (4401 mutations in 6436 cases). The gene discussed is TP53; the disease is cancer.