A recent review by Jung et al. addressed these issues [40] and found how a number of TLR4 ligands (S100A8/A9, S100A12, MPO-DNA complex, high mobility group box 1 (HMGB1), and NET molecules), while contributing to inflammation, may be reliable biomarkers for evaluating disease activity in AOSD. The gene discussed is HMGB1; the disease is adult-onset Still disease.