CD8A and neoplasm: Additionally, it was reported that VISTA is mainly expressed on immune cells, especially CD8+ T cells, and is associated with immunosuppressive conditions in various tumor types, including melanoma, acute myeloid leukemia (AML), hepatocellular carcinoma (HCC), small-lung-cell carcinoma, gastric cancer, and colorectal cancer, as reviewed in detail by ElTanbouly et al. [83] and Tagliamento et al. [84].