HMGB1 and cancer: In this case (Figure 9B), we observed that some of the identified proteins/genes had already been correlated with resistance, such as PA2G4 and thioredoxin (TXN) in breast cancer [36], high-mobility group box 1 (HMGB1) in several cancer types [37], S100A11 in prostate cancer [38] and heat shock proteins and chemokine (C-C motif) ligand 2 (CCL2) in multiple contexts.