This is the case for some of the proteins (not necessarily cytokines, but tyrosine kinases, enzymes, chaperones and others) selected in our analysis: SERPINE1, for example, has been described as a mediator of EMT and a metastasis through STAT3 signalling [56]; ADAM12, as a regulator of a proangiogenic TME [57]; and chaperones such as HSP27, HSP70, HSP90 and HSP110 control the activation of STAT3/5 to stimulate cancer cell proliferation and survival, immunosuppression and eventually tumour progression [58]. The gene discussed is ADAM12; the disease is cancer.