In view of our data (cf. Figure 1A,C), the most challenging to discuss remain the results obtained by García-Pastor et al. [29], who found that HIF-1α response to hypoxia is impaired in HK-2 cells cultured in the presence of high glucose (25 mM) and demonstrated that hyperglycemia disrupts HIF-1α interaction with Hsp90, resulting in its accelerated degradation in proteasome. Here, HIF1A is linked to Hyperglycemia.