In another in vivo study on BALB/c mice with liver fibrosis induced by CCl4, exosomes from hUC-MSC inhibited hepatocyte apoptosis by reducing the expression of activated caspase 3, and Bax and 8-Oxo-2’-deoxyguanosine (8-OHdG) production [97]. The gene discussed is CASP3; the disease is Hepatic fibrosis.