In regard to thrombosis, the effects of IL-33 on monocytes might be of even greater interest, since monocytes and monocyte-derived MVs are one of the main sources of circulating TF and contribute to the formation of a prothrombotic environment in patients with cardiovascular disease through the propagation of coagulation upon plaque rupture [84,85,86]. The gene discussed is IL33; the disease is cardiovascular disorder.