Indeed, apart from the various studies revealing the dysregulated expression of inflammatory-related genes and proteins in ALS patient tissues [3], and the implication of several signaling kinases in the pathophysiology of ALS [14], the recent discovery of TBK1 as an ALS-causing gene [15,16] suggests a direct link between neuroinflammation and signaling kinases in ALS and other related diseases. This evidence concerns the gene TBK1 and amyotrophic lateral sclerosis.