TBK1 and amyotrophic lateral sclerosis: Even though there is no causal evidence linking RIPK1 mutations to ALS, this gene was shown to mediate axonal degeneration by promoting inflammation and subsequent oligodendrocytes necroptosis in ALS [33], and a proinflammatory role of RIPK1 kinase activity in the CNS in association with TBK1 was demonstrated, as mentioned above [27].