TARDBP and amyotrophic lateral sclerosis: Furthermore, the accumulation of ubiquitinated protein aggregates in degenerating neurons and other CNS cell types, particularly cytoplasmic TDP-43 species and C9orf72 dipeptide-repeat protein (DPR) aggregates, are also a common denominator in tissue samples from ALS and FTD patients, both familial and sporadic [10].