Combined proteomic and glycomic profiling of HDL particles in 10 patients with coronary angiographically verified coronary atherosclerosis and 10 control group individuals revealed a lower blood content of HDL apolipoproteins (in particular, ApoA-I, ApoA-II and apoE), serum amyloid A2 (SAA2), but a higher content of sialylated glycans in patients with coronary heart disease. This evidence concerns the gene APOE and coronary atherosclerosis.