In the urine proteome of patients with MI, 12 differentially expressed proteins were associated with atherosclerosis, abnormal coagulation and abnormal cell metabolism, and five proteins (antithrombin-III, complement C3, α-1-acid glycoprotein 1, serotransferrin and cathepsin Z) were first associated with MI. The gene discussed is SERPINC1; the disease is atherosclerosis.