An analysis of the systemic biology of changes in high-density lipoprotein (HDL) protein in blood serum caused by percutaneous transluminal coronary angioplasty (PTCA) in patients with CHD revealed an increase in apolipoprotein proteins, fibrinogen-like protein 1, as well as a decrease in antithrombin-III, annexin A1 and several immunoglobulins [12]. This evidence concerns the gene ANXA1 and coronary artery disorder.