The analysis showed that apolipoprotein C-II (APOC2), dedicator of cytokinesis protein 2 (DOCK2), ligand 7 (CXCL7) and vitamin D binding protein (VTDB) were activated, and complement 4A (C4A) were suppressed in diabetic patients and were associated with severe coronary artery stenosis. The gene discussed is DOCK2; the disease is coronary stenosis.