The results showed that several important proteins, such as myeloperoxidase, arachidonate-12-lipoxygenase, histidine-rich glycoprotein, Crk-like protein, vitronectin, thrombospondin 1, apolipoprotein H, apolipoprotein AI, complement component C3, clusterin were present in the platelets of stroke patients. The gene discussed is CRKL; the disease is Stroke.