Having compiled a proteomic map of apolipoproteins in different lipoprotein fractions (LDL, HDL), Lepedda and colleagues found that the level of SAA was increased in all lipoprotein fractions in atherosclerosis, but in the LDL fraction, its level was especially high (an increase of 14 times), which shows the connection of this protein with the development of the pathological atherosclerotic process in the carotid arteries [53]. The gene discussed is SAA2; the disease is atherosclerosis.