To elucidate the role of retromer in the pathogenesis of NPC disease, in this work, we characterized the levels and the localization/distribution of retromer proteins (Vps26 and Vps35) and retromer receptor sorLA in NPC1-null cells and in different brain regions of NPC1 mice (cerebellum, cortex and hippocampus) at different disease stages (4, 7 and/or 10-week old). This evidence concerns the gene SORL1 and nasopharyngeal carcinoma.