Guendalina and colleagues suggested that oncolytic viruses can successfully activate antitumor immunity via the activation of a STING-dependent antiviral cascade in cancer cells [77].The nucleoside analog zalcitabine (an antiviral drug) induces mitochondrial damage and the release of mtDNA into the cytosol, resulting in the activation of the cGAS–STING pathway, which in turn induces autophagy-dependent ferroptosis and suppresses pancreatic tumor growth in mice [78]. This evidence concerns the gene STING1 and pancreatic neoplasm.