For instance, MBNL1 is responsible for the regulation of ABLIM1 (actin-binding LIM protein 1) exon11 and CLCN1 (muscle chloride channel) exon7a splicing, which are dysregulated due to sequestration of MBNL1 in the expansion RNAs in DM1. This evidence concerns the gene ABLIM1 and myotonic dystrophy type 1.