It is well known that NAFLD has strong hereditable traits and several genetic polymorphisms on the Patatin-like Phospholipase Domain-containing 3 (PNPLA3) genes and Transmembrane 6 Superfamily Member 2 (TM6SF2) gene have been identified with associated risks for NAFLD and increased risk for HCC [10]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.