PTEN and glioblastoma: In the TCGA project, a comprehensive genomic characterization study for GBM, some significant mutations, and somatic genome alterations were detected, including TP53, EGFR, PTEN, NF1, PIK3CA PIK3R1, RB1, SPTA1, ATRX, IDH1, KEL, PDGFRA, and GABRA6.