PTEN and glioblastoma: Moreover, to produce biological data, GBM models made by both animal and cell lines could be developed by silencing tumor suppressors, such as P53, NF1, PTEN, RB/p107/p130 or the activation of oncogenes, such as EGFR, HRasV12, KRasG12D, PDGF, and virus intervention [29,30].