In the TCGA project, a comprehensive genomic characterization study for GBM, some significant mutations, and somatic genome alterations were detected, including TP53, EGFR, PTEN, NF1, PIK3CA PIK3R1, RB1, SPTA1, ATRX, IDH1, KEL, PDGFRA, and GABRA6. The gene discussed is TP53; the disease is glioblastoma.