Factors which affect the level of Flii have yet to be fully identified; however, Flii has been shown to have several binding partners which regulate actin dynamics (e.g., paxillin, talin), transcription and translation (e.g., LRRFIP1, Akt, Ulk1) and inflammation (e.g., LPS, caspase-1, LRRFIP2, Myd88) via signaling pathways important during cancer progression [14]. The gene discussed is LRRFIP1; the disease is cancer.