Future studies could investigate the effect of Flii on factors that promote cSCC epithelial to mesenchymal transition, including the level of TGF and BMP at the tumor site [45] and Wnt5 and ROR2 expression at the leading edge of cSCC, which have been shown to regulate Snail-medicated EMT and invasive properties of cancer cells [47]. The gene discussed is ROR2; the disease is cancer.