We first investigated the localization and expression of Flii, β-catenin, Axin2, Flap-1 and SOX9 in immortalized human keratinocytes (HaCaT) and tumorigenic MET-1 cell line established from a patient with late-stage aggressive metastatic cSCC [22,32]. This evidence concerns the gene LRRFIP1 and skin squamous cell carcinoma.