A number of studies have shown both beneficial and detrimental effects of Flii in cancer progression (for a detailed review see [14]); however, in the context of human cSCC, increased Flii within invading cells at the tumor edge and overexpression in a mouse model of cSCC lead to significantly larger, more necrotic tumors due to decreased apoptosis and increased invasion of tumor cells [22]. Here, FLII is linked to neoplasm.