IL13 and eosinophilic esophagitis: IL–13 overexpression with the CC10–rtTA–IL13 transgenic system in response to exogenous doxycycline is sufficient to induce alteration resembling EoE, i.e., esophageal eosinophilia, tissue remodeling of the esophagus: increased esophageal circumference, increased epithelial cell proliferation primarily associated with the basal zone, collagen deposition, and increased angiogenesis in the lamina propria [38].