Surprisingly, CAPN14 realtime PCR expression in EoE patients’ biopsies with risk haplotype at 2p23 (i.e., having at least one of the EoE risk alleles at each of the six most highly associated variant locations) was 30% lower than in EoE patients with the non-risk haplotype (without EoE risk alleles). Here, CAPN14 is linked to eosinophilic esophagitis.