DSG1 is considered to be involved in pathogenesis of atopic diseases, e.g., homozygous mutations in DSG1 causes severe dermatitis, multiple allergies, and metabolic wasting (SAM syndrome); autoimmunization against DSG1 causes pemphigus foliaceus, a skin blistering disease, which manifests as severe loss of epithelial integrity, compromised BF and skin lessions [44]. Here, DSG1 is linked to skin disorder.