CAPN14 and eosinophilic esophagitis: It can be hypothesized that the CDH26 increase in active EoE and EG is involved in both promoting diseases, i.e., by increasing migration of some cell types that occur in inflamed mucosa and epithelium in EoE or by some other ways, and resolution of inflammation, inhibiting and dampening Th2–mediated activation to promote the return of the tissue to homeostasis (similar to CAPN14 mode of action in epithelial cells, see further).